Crosstalk between Dysferlin and Integrin ß3 regulates cell contacts in human monocytes
نویسندگان
چکیده
1 Department of human genetics, Leiden University Medical Center, Leiden, The Netherlands 2 Department of rheumatology, Leiden University Medical Center, Leiden, The Netherlands 3 Servei de Neurologia, Laboratori de Neurologia Experimental, Hospital de la Santa Creu i Sant Pau i Institut de Recerca de HSCSP, Universitat Autònoma de Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Spain.
منابع مشابه
Dysferlin regulates cell adhesion in human monocytes.
Dysferlin is mutated in a group of muscular dystrophies commonly referred to as dysferlinopathies. It is highly expressed in skeletal muscle, where it is important for sarcolemmal maintenance. Recent studies show that dysferlin is also expressed in monocytes. Moreover, muscle of dysferlinopathy patients is characterized by massive immune cell infiltrates, and dysferlin-negative monocytes were s...
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تاریخ انتشار 2011